The Papers of Sir Robert Edwards (2)

10th June 2019 in Archives Centre, Our Collections

The archive of Professor Sir Robert Edwards (IVF pioneer) is open for research following an 18 month project to catalogue and conserve the papers. The project was generously funded by the Wellcome Trust and Churchill Archives Centre is grateful for their support.

The Edwards papers were deposited at Churchill Archives Centre in 12 separate lots between 2010 and 2018. Most of the papers came from Edwards’ family home and from Bourn Hall (the IVF clinic he established).

Panoramic photo of Bourn Hall

Panorama of Bourn Hall, [1979], EDWS 18/8/4.

Cataloguing the papers has been extremely interesting and we are looking forward to seeing how the collection is used. The papers will be valuable for researchers in the history of science and medicine, but also in the history of ethics, social implications of medical developments, political history, history of the media, and the history of scientific publishing.

The archive is strong on the political, legal, religious and social reaction to IVF and other assisted reproductive technologies. There are plenty of letters, video clips of news stories, cuttings from newspapers, drafts of articles and conference papers relating to these issues.

Although the Edwards papers have been closed to researchers during cataloguing, there was an opportunity to display one of the items from the archive in an exhibition at the Science Museum in London in 2018. We lent the Museum a notebook that was used to record early clinical trials that led to the eventual first success of IVF. The exhibition ‘IVF: 6 Million Babies Later’ celebrated 40 years of IVF, and explored the history and current state of IVF technologies. You can read more about the exhibition and the clinical research notebook which was displayed in our previous blog post.

One of Edwards's notebooks on display

Photo: A clinical research notebook from the Papers of Professor Sir Robert Edwards on display at the Science Museum in 2018

For this blog post I have decided to focus on one aspect of the papers that I found particularly interesting throughout the project – Edwards’ collaborations.

In the UK Edwards had trouble convincing doctors to work with him on human fertility. The National Institute of Medical Research at Mill Hill (where he worked from 1958-1963) would not support experiments on fertilising human eggs. In 1963 after a short stint in Glasgow, Edwards moved to Cambridge to work at the Physiological Laboratory. There he continued work on immunology and the fertilisation of eggs (usually with the eggs of cows, sheep and monkeys) but it still proved difficult to obtain human eggs for experimentation.

In 1965 Robert Edwards travelled to the United States for a six-week research trip to Johns Hopkins University Hospital in Baltimore. It was easier to get hold of human oocytes for experiments in the United States and Edwards was able to conclude that it took 36 hours for eggs to ripen (though he failed to fertilise any).

During his trip to Baltimore Edwards met Howard and Georgeanna Jones for the first time. The Joneses became pioneers of IVF in the United States and remained close colleagues and friends with Edwards throughout his life.

Edwards with Howard and Georgeanna Jones

Photo: Robert Edwards with Howard and Georgeanna Jones (pioneers of IVF in the United States), November 2000, EDWS 18/4/55.

The Washington Star newspaper reported, on 21 Nov 1978, that Edwards and Steptoe had agreed to advise researchers at Eastern Virginia Medical School on IVF (archive ref. EDWS 1/1/1/48). Following their advice, the first American IVF baby (Elizabeth Carr) was born in 1981 at the Jones Institute for Reproduction Medicine at Eastern Virginia Medical School.

In letters written from Baltimore to his wife (Ruth) in Cambridge, Edwards outlined in great detail the research taking place. The detail in these letters show how the research was progressing, and how significant this trip must have been to Edwards’ future success.

letter to Ruth Edwards from Robert Edwards

Photo: The first page of a letter to Ruth Edwards from Robert Edwards in Baltimore, 22 July 1965, EDWS 17/3.

After Edwards’ first day at Johns Hopkins Hospital, 13 July 1965, he had 32 eggs in culture. He wrote:

“So far two intact ovaries have been provided – it’s amazing the difference in approach here – most gynaecologists are really interested in what goes on and want to try new things. By tomorrow our technologies should be vastly improved, and by the next day we should really be on the way”.

On the 22 of July:

“After what seems years of effort I’ve at long last seen a beautiful human egg with metaphase II chromosomes and polar bodies – just awaiting fertilization….Howard Jones the gynaecologist is most interested – and he has been very kind too.”

Later, on the 1 of August:

“And now the last research effort here begins. 1 week and possibly 10 days to fertilise those eggs! There is no difficulty getting to the PB [polar body] stage – it is just fertilization”

In ‘A Matter of Life’ (1980) Edwards stated "Those weeks in Johns Hopkins were decisive for me. Though we had failed to fertilize one single human egg, I was not deterred. I felt confident I could solve that problem eventually” (pg. 54).

The letters Edwards wrote to his wife from Johns Hopkins provide detail of exactly what kind of experiments he was conducting, who he met and who helped in the research. I feel certain that this will be of great use for researchers looking into the science and origins of IVF and other infertility treatments.

The papers of Robert Edwards also shed light on the collaboration between Edwards, Patrick Steptoe and Jean Purdy. Although it was only Edwards who won the Nobel Prize (they can’t be awarded posthumously) all three members of the team were responsible for the breakthrough in IVF, and brought a different key ingredient to the discovery.

Patrick Steptoe was a gynaecologist and pioneer of laparoscopy – a surgical technique which involved inserting a camera through the navel to inspect the uterus. Steptoe had been using the laparoscope for sterilisation and diagnosis, and it became an essential tool for collecting eggs for IVF.

Patrick Steptoe performing a laparoscopy

Photo: Patrick Steptoe performing a laparoscopy, [c.1968-1978], EDWS 18/1/4.

In ‘Tribute to Patrick Steptoe: beginnings of laparoscopy’ (1989) Edwards described how he first became aware of Steptoe’s pioneering work through reading an article by Steptoe in The Lancet in 1968. Edwards subsequently called Steptoe to discuss a possible collaboration.

Elliot Philipp (gynaecologist and obstetrician) recalled that Steptoe and Edwards first met in person later in 1968, 6 months after Edwards had called Steptoe on the telephone. He recollects that Edwards’ initial interest was in developing stem cells from human eggs, and it was Steptoe who suggested making an embryo outside of the human body and reintroducing it to bypass blocked fallopian tubes. Philipp wrote “You both agreed however, that making an embryo or several embryos outside the human body and replacing them within the uterus would be a good way of bypassing blocked fallopian tubes; and that is what you decided on, rather than your initial request of making stem cells” (archive ref. EDWS 1/1/1/111, letter from Elliot Philipp to Edwards, 30 July 2003).

Jean Purdy was a lab technician, nurse and the first ever embryologist. She started working for Edwards in 1968, and co-authored many books and articles with him. Edwards and Steptoe wrote that Purdy had contributed equally to the birth of Louise Brown and the establishment of IVF centres in Kershaw’s Hospital, Oldham and Bourn Hall (preface to ‘Implantation of the Human Embryo: Proceedings of the second Bourn Hall meeting’ dedicated to Purdy, 1985).

“She shared all of the scientific work and much of the clinical work, being the first to describe the formation of the human blastocyst in vitro, designing the first aspiration catheter, sharing in the introduction of urinary assays for LH [luteinising hormone] and participating in so many other aspects of the work” (Edwards and Steptoe, July 1985, EDWS 4/2/2/4).

Robert Edwards,  Patrick Steptoe, Lesley Brown, Louise Brown and Jean Purdy

Photo: Robert Edwards, Patrick Steptoe, Lesley Brown, Louise Brown and Jean Purdy. Taken at Louise Brown’s first birthday party, 1979, EDWS 18/9/1/4.

Edwards and Purdy travelled to and from Oldham, where Steptoe was based, during a decade of clinical research (1968-1978) which led to the eventual success of IVF. The notebooks from this clinical research phase are full of Purdy’s handwriting.

Purdy also travelled to California in 1969 to work with Guy Abraham at Harbor General Hospital on the composition of follicular fluid. Follicular fluid was an area which needed more research for IVF to work. The archive contains detailed letters from Purdy to Edwards sent during her research trip to California. These letters are long and full of results from experiments, they show just how key Purdy was to the science behind IVF.

Patrick Steptoe and Jean Purdy appear throughout the Edwards papers: through their handwriting, joint publications with Edwards, correspondence and photographs. There is even a section of Steptoe’s papers within the Edwards archive (EDWS 16, 2 archive boxes). These papers were left at Bourn Hall after Steptoe’s death in 1988 and include correspondence, draft publications, and information on conferences he attended. 

The Papers of Professor Sir Robert Edwards are now open for research (except specific closures marked in the catalogue). 

Catalogue to the Edwards Papers

Please get in touch with the team if you would like to make an appointment to view the papers:

archives@chu.cam.ac.uk

For those interested in the history of IVF you may like to note that the Lesley Brown papers are newly available at Bristol Archives. Lesley Brown was the mother of Louise Brown (the first baby born through IVF).

Bristol Archives blog post.

For more information about the history of Bourn Hall Clinic see the clinic’s blog:

Bourn Hall blog post.

—Madelin Evans, Archivist


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